KMID : 0882420080740030325
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Korean Journal of Medicine 2008 Volume.74 No. 3 p.325 ~ p.329
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A case of Graves¡¯ disease associated with Turner¡¯s syndrome
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Chung Jin-Ook
Chung Dong-Jin Chung Min-Young Cho Dong-Hyeok
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Abstract
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It is becoming increasingly evident that adults with Turner¡¯s syndrome are susceptible to endocrine autoimmunity. An increased prevalence of thyroid autoantibodies and hypothyroidism in patients with Turner¡¯s syndrome has been reported, but the involvement of Graves¡¯ disease in these patients is relatively rare. We describe a case of Graves¡¯ disease associated with Turner¡¯s syndrome. A 28-year-old woman was referred for diffuse anterior neck swelling and palpitation. She had been diagnosed with Turner¡¯s syndrome with monosomy 45,X before the age of 9 years and she took estrogen together with progesterone. The physical examination revealed a firm, non-tender goiter. The T3 level was 632 ng/dL, the free T4 level was 5.68 ng/dL, the TSH level was 0.02 ¥ìIU/mL, the % of TSH-binding inhibiting immunoglobulin was 24% and the anti-thyroid autoantibodies were positive. The radioactive iodine uptake was increased. Therefore, she was diagnosed as having Graves¡¯ disease. (Korean J Med 74:325-329, 2008)
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KEYWORD
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Graves¡¯ disease, Turner syndrome
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